Significant differences in drug susceptibility among species in the Candida parapsilosis group

Eveline van Asbeck; Karl V Clemons; Marife Martinez; Ann-Jay Tong; David A Stevens

doi:10.1016/j.diagmicrobio.2008.04.019

Significant differences in drug susceptibility among species in the Candida parapsilosis group

Diagn Microbiol Infect Dis. 2008 Sep;62(1):106-9. doi: 10.1016/j.diagmicrobio.2008.04.019. Epub 2008 Jun 13.

Authors

Eveline van Asbeck¹, Karl V Clemons, Marife Martinez, Ann-Jay Tong, David A Stevens

Affiliation

¹ Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.

PMID: 18555634
DOI: 10.1016/j.diagmicrobio.2008.04.019

Abstract

Candida parapsilosis family has 3 proposed species: C. parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. C. parapsilosis sensu stricto had significantly higher caspofungin (CAS) and anidulafungin MICs than C. orthopsilosis or C. metapsilosis; C. metapsilosis was least susceptible to fluconazole. C. parapsilosis sensu stricto more frequently displayed (37%) paradoxical growth in CAS (P < or = 0.02). These species susceptibility differences could affect therapeutic choices.

MeSH terms

Anidulafungin
Antifungal Agents / pharmacology*
Candida / classification
Candida / drug effects*
Candida / genetics
Candidiasis / microbiology
Caspofungin
Echinocandins / pharmacology*
Fluconazole / pharmacology*
Humans
Lipopeptides
Microbial Sensitivity Tests
Random Amplified Polymorphic DNA Technique

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Fluconazole
Anidulafungin
Caspofungin