Abstract
We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Atazanavir Sulfate
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Drug Therapy, Combination
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Electrocardiography / drug effects
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HIV Infections / drug therapy*
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HIV Protease Inhibitors / adverse effects*
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Humans
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Male
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Methadone / therapeutic use
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Middle Aged
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Narcotics / therapeutic use
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Oligopeptides / adverse effects*
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Pyridines / adverse effects*
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Ritonavir / therapeutic use
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Tachycardia, Ventricular / chemically induced*
Substances
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HIV Protease Inhibitors
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Narcotics
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Oligopeptides
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Pyridines
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Atazanavir Sulfate
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Ritonavir
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Methadone