Combination iminium, enamine and copper(I) cascade catalysis: a carboannulation for the synthesis of cyclopentenes

Chem Commun (Camb). 2008 Jul 7:(25):2923-5. doi: 10.1039/b802416b. Epub 2008 Apr 21.

Abstract

A one-pot, multistep reaction cascade to cyclopentenes from alpha,beta-unsaturated ketones and propargylated carbon acids through a combination of organocatalysis and transition metal ion catalysis is reported; the reaction cascade is simple to perform, occurs under mild conditions and is broad in scope.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Carbon / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Cyclopentanes / chemical synthesis*
  • Cyclopentanes / chemistry
  • Imines / chemistry*
  • Molecular Structure

Substances

  • Alkynes
  • Amines
  • Cyclopentanes
  • Imines
  • Carbon
  • Copper