Short PET in pediatric peritoneal dialysis

Pediatr Nephrol. 2008 Oct;23(10):1853-8. doi: 10.1007/s00467-008-0892-0. Epub 2008 Jun 25.

Abstract

Peritoneal equilibration test (PET) is a common technique used in children to evaluate peritoneal membrane transport capacity and adequate the dialysis regimen. Considering that this is a laborious test, a shortened version has been proposed. Our goal was to evaluate the concordance between the 2-h (short) and 4-h (classical) PET values to determine whether the short PET could be used in the clinical setting. Eighty-one PET corresponding to 81 peritoneal dialysis patients from two pediatric nephrology centers were retrospectively analyzed. Peritoneal transport capacity was evaluated using the dialysate to plasma ratio (D/P) of creatinine and the ratio of dialysate glucose to baseline dialysate glucose (D/D(0)) at 2 and 4 h. The mean [+/- standard deviation (SD)] creatinine D/P ratio at 2 and 4 h were 0.41 +/- 0.13 and 0.66 +/- 0.17, respectively, and the mean (+/- SD) D/D(0) glucose were 0.64 +/- 0.11 and 0.39 +/- 0.12 at the same times. Applying McNemar chi(2) test to evaluate the association between the categories obtained at 2 and 4 h, we found no relationship between the 2- and 4-h PET for both D/P and D/D(0) (p > 0.05). These results suggest that the use of this abbreviated test is probably not reliable for estimating the transport capacity of the peritoneal membrane in the pediatric population.

MeSH terms

  • Adolescent
  • Biological Transport
  • Blood Glucose / analysis
  • Child
  • Child, Preschool
  • Creatinine / blood
  • Female
  • Humans
  • Infant
  • Male
  • Peritoneal Dialysis*
  • Peritoneum / metabolism*

Substances

  • Blood Glucose
  • Creatinine