A protein-DNA docking benchmark

Nucleic Acids Res. 2008 Aug;36(14):e88. doi: 10.1093/nar/gkn386. Epub 2008 Jun 26.

Abstract

We present a protein-DNA docking benchmark containing 47 unbound-unbound test cases of which 13 are classified as easy, 22 as intermediate and 12 as difficult cases. The latter shows considerable structural rearrangement upon complex formation. DNA-specific modifications such as flipped out bases and base modifications are included. The benchmark covers all major groups of DNA-binding proteins according to the classification of Luscombe et al., except for the zipper-type group. The variety in test cases make this non-redundant benchmark a useful tool for comparison and development of protein-DNA docking methods. The benchmark is freely available as download from the internet.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • DNA / chemistry*
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / classification
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Binding
  • Protein Conformation

Substances

  • DNA-Binding Proteins
  • DNA