Abstract
X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu(2+) in Abeta-Cu(2+) complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric Abeta-Cu(2+) complexes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Absorption
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Alzheimer Disease / metabolism*
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Amino Acid Sequence
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism*
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Copper / metabolism*
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Molecular Sequence Data
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Oxidation-Reduction
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Thermodynamics
Substances
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Amyloid beta-Peptides
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Copper