Abstract
The synthesis of some 2-aminobenzimidazole and indole amide derivatives containing a 2,6-dichloroaniline moiety is described. The preparation of a theophylline derivative is also reported. All the compounds tested showed no appreciable antihypertensive activity on spontaneously hypertensive rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antihypertensive Agents / chemical synthesis*
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Blood Pressure / drug effects
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Clonidine / pharmacology
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Hypertension / physiopathology
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Male
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Rats
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Rats, Inbred SHR
Substances
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Antihypertensive Agents
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Benzimidazoles
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Indoles
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2-aminobenzimidazole
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Clonidine