Abstract
A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus DeltacnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus fumigatus / enzymology*
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Aspergillus fumigatus / genetics
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Aspergillus fumigatus / growth & development*
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Calcineurin / genetics
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Calcineurin / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Hyphae / enzymology*
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Hyphae / genetics
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Hyphae / growth & development
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Protein Transport
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Spores, Fungal / enzymology
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Spores, Fungal / genetics
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Spores, Fungal / growth & development*
Substances
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Fungal Proteins
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Calcineurin