Abstract
Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector.
MeSH terms
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DNA, Viral / genetics
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DNA, Viral / metabolism*
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HIV Infections / virology
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HIV Integrase / genetics
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HIV-1 / enzymology
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HIV-1 / genetics*
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HIV-1 / metabolism
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Human Immunodeficiency Virus Proteins / genetics
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Human Immunodeficiency Virus Proteins / metabolism*
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Humans
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Time Factors
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Transcription, Genetic
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Virion / metabolism
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Virus Integration / physiology*
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Virus Replication
Substances
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DNA, Viral
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Human Immunodeficiency Virus Proteins
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HIV Integrase