Abstract
This investigation describes the catalytic asymmetric addition of dimethylzinc to alpha-ketoesters in the presence of (-)-MITH ( 5) and triethyl borate as an additive to give the corresponding chiral alpha-hydroxy esters with good yields and high enantioselectivities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemistry
-
Camphanes / chemistry*
-
Catalysis
-
Esters / chemistry*
-
Ketones / chemistry*
-
Ligands
-
Morpholines / chemistry
-
Organometallic Compounds / chemistry*
-
Stereoisomerism
-
Sulfhydryl Compounds / chemistry
Substances
-
Aldehydes
-
Camphanes
-
Esters
-
Ketones
-
Ligands
-
Morpholines
-
Organometallic Compounds
-
Sulfhydryl Compounds
-
dimethylzinc