Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830

Miho Izumikawa; Hisayuki Komaki; Junko Hashimoto; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2008.47

Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830

J Antibiot (Tokyo). 2008 May;61(5):326-9. doi: 10.1038/ja.2008.47.

Authors

Miho Izumikawa¹, Hisayuki Komaki, Junko Hashimoto, Motoki Takagi, Kazuo Shin-ya

Affiliation

¹ Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), Aomi, Tokyo, Japan.

PMID: 18654000
DOI: 10.1038/ja.2008.47

Abstract

A stawamycin analog, JBIR-11 (1) was isolated from mycelium of Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830. The structure was determined on the basis of the spectroscopic data. Compound 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 25 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / biosynthesis
Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology*
Cell Line, Tumor
Chemical Phenomena
Chemistry, Physical
Humans
Indoles / isolation & purification
Indoles / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Conformation
Mycelium / chemistry
Pyrroles / isolation & purification
Pyrroles / pharmacology*
Spectrophotometry, Ultraviolet
Streptomyces / chemistry
Streptomyces / metabolism*

Substances

Antibiotics, Antineoplastic
Indoles
JBIR-11
Pyrroles