Can stereotactic fractionated radiation therapy become the standard of care for early stage non-small cell lung carcinoma

Cancer Treat Rev. 2008 Dec;34(8):719-27. doi: 10.1016/j.ctrv.2008.06.001. Epub 2008 Jul 26.

Abstract

Management of early stages non-small cell lung carcinoma has traditionally been surgery with radiation selected for medically inoperable patients. Recent emergence of stereotactic body radiation therapy allows for delivery of high radiation dose to the tumor while sparing normal lungs. This reviews compares loco-regional control, survival and complications rates between these two treatment modalities. Literature search identifies studies with stereotactic body radiation therapy and surgery for early stages non-small cell lung cancer. Effectiveness and toxicity of these two modalities was assessed. Stereotactic body radiation therapy is associated with minimal morbidity and provides comparable local control and survival in patients with multiple co-morbidities factors. Stereotactic body radiation therapy may become standard of care for operable early stages non-small cell lung cancer.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Aged
  • Carcinoma, Non-Small-Cell Lung / mortality*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / surgery*
  • Female
  • Humans
  • Lung Neoplasms / mortality*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Pneumonectomy / methods
  • Prognosis
  • Radiation Injuries / epidemiology
  • Radiation Injuries / prevention & control
  • Radiation Pneumonitis / epidemiology
  • Radiation Pneumonitis / prevention & control
  • Radiosurgery / adverse effects
  • Radiosurgery / methods
  • Radiosurgery / standards*
  • Randomized Controlled Trials as Topic
  • Reference Standards
  • Risk Assessment
  • Sensitivity and Specificity
  • Survival Analysis
  • Thoracic Surgery, Video-Assisted / methods*
  • Treatment Outcome