Abstract
We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anthracenes / chemical synthesis*
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Anthracenes / chemistry*
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Anthracenes / radiation effects
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DNA / chemistry*
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DNA / radiation effects
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Molecular Structure
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Nucleic Acid Conformation
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Oligonucleotides / chemistry
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Oligonucleotides / radiation effects
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Stereoisomerism
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Ultraviolet Rays
Substances
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Anthracenes
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Oligonucleotides
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catenane
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DNA