PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation

Maria-Luisa del Rio; Leo Buhler; Carrie Gibbons; Jiong Tian; Jose-Ignacio Rodriguez-Barbosa

doi:10.1111/j.1432-2277.2008.00726.x

PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation

Transpl Int. 2008 Nov;21(11):1015-28. doi: 10.1111/j.1432-2277.2008.00726.x. Epub 2008 Jul 25.

Authors

Maria-Luisa del Rio¹, Leo Buhler, Carrie Gibbons, Jiong Tian, Jose-Ignacio Rodriguez-Barbosa

Affiliation

¹ Laboratory of Immunobiology, School of Biotechnology and Institute of Biomedicine, University of Leon, Leon, Spain.

PMID: 18662368
DOI: 10.1111/j.1432-2277.2008.00726.x

Abstract

Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antibodies, Monoclonal / pharmacology
Antigen-Presenting Cells / immunology*
Antigens, CD / immunology
Antigens, CD / physiology*
Apoptosis Regulatory Proteins / physiology*
B7 Antigens
B7-1 Antigen / immunology
B7-H1 Antigen
Graft Rejection / immunology
Humans
Intercellular Signaling Peptides and Proteins / physiology
Mice
Programmed Cell Death 1 Ligand 2 Protein
Programmed Cell Death 1 Receptor
Receptors, Immunologic / immunology
Receptors, Tumor Necrosis Factor, Member 14 / immunology
Signal Transduction / immunology
T-Lymphocytes, Regulatory / drug effects
T-Lymphocytes, Regulatory / immunology
Transplantation Immunology / immunology*

Substances

Antibodies, Monoclonal
Antigens, CD
Apoptosis Regulatory Proteins
B7 Antigens
B7-1 Antigen
B7-H1 Antigen
CD274 protein, human
CD276 protein, human
Cd276 protein, mouse
Intercellular Signaling Peptides and Proteins
PDCD1 protein, human
PDCD1LG2 protein, human
Pdcd1lg2 protein, mouse
Programmed Cell Death 1 Ligand 2 Protein
Programmed Cell Death 1 Receptor
Receptors, Immunologic
Receptors, Tumor Necrosis Factor, Member 14
TNFRSF14 protein, human