[Placental mesenchymal dysplasia]

Ann Pathol. 2008 Apr;28(2):85-94. doi: 10.1016/j.annpat.2008.03.005. Epub 2008 Jul 2.
[Article in French]

Abstract

Placental mesenchymal dysplasia (PMD) is a recently described entity. Because of the presence of an embryo and a multicystic placenta, it has been initially misinterpreted as a partial mole on ultrasound as well as on gross examination. However, careful microscopic examination, cytogenetic analyses, molecular studies and follow-up of children allowed to better understand this placental abnormality, allowing an antenatal diagnosis. Our purpose was to describe ultrasonographic, macroscopic and microscopic features in PMD on the basis of a literature review and our own experience. We also detailed clinical presentation, complications of pregnancy and fetopathologic associations. We discussed ethiopathogenic hypotheses as well as differential diagnoses.

MeSH terms

  • Chorionic Villi / diagnostic imaging
  • Chorionic Villi / pathology
  • Diagnosis, Differential
  • Embryonic Development
  • Female
  • Fetal Death / diagnostic imaging
  • Fetal Death / pathology
  • Humans
  • Hydatidiform Mole / diagnostic imaging
  • Hydatidiform Mole / pathology
  • Infant, Newborn
  • Male
  • Placenta / pathology
  • Placenta Diseases / diagnostic imaging
  • Placenta Diseases / pathology*
  • Placenta Diseases / surgery
  • Pregnancy
  • Pregnancy Complications / diagnostic imaging
  • Pregnancy Complications / pathology*
  • Pregnancy Complications / surgery
  • Ultrasonography