Abstract
The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher's method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dinoflagellida / chemistry
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Macrolides / chemistry*
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Models, Molecular
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Molecular Conformation
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Nuclear Magnetic Resonance, Biomolecular / methods
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Stereoisomerism
Substances
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Macrolides
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amphidinolide Q