G-Quadruplex formation interferes with P1 helix formation in the RNA component of telomerase hTERC

Chembiochem. 2008 Sep 1;9(13):2075-9. doi: 10.1002/cbic.200800300.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • G-Quadruplexes*
  • Guanine / chemistry
  • Guanine / metabolism
  • Humans
  • Ligands
  • Molecular Sequence Data
  • Mutation
  • Nucleic Acid Conformation / drug effects
  • Nucleic Acid Denaturation
  • Oligoribonucleotides / chemistry
  • Oligoribonucleotides / genetics
  • Oligoribonucleotides / metabolism
  • Pyridines / pharmacology
  • Quinolines / pharmacology
  • RNA / chemistry*
  • RNA / metabolism
  • Substrate Specificity
  • Telomerase / chemistry*
  • Telomerase / genetics*
  • Transition Temperature

Substances

  • 2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide
  • Ligands
  • Oligoribonucleotides
  • Pyridines
  • Quinolines
  • Guanine
  • RNA
  • Telomerase