Iatrogenic injuries to the extrahepatic biliary tract are rare during urologic laparoscopy. A few cases of gallbladder injury have been reported; however, to our knowledge, no instance of common bile duct (CBD) injury during urologic laparoscopy has hitherto been described. Out of 2866 transperitoneal laparoscopic urologic procedures between 1997 and 2007, we present two patients who sustained iatrogenic CBD injury, one during laparoscopic anterior pelvic exenteration and Indiana pouch diversion, and the other during laparoscopic partial nephrectomy. Etiology, management, and preventive strategies are summarized.