The human papillomavirus type 8 E2 gene encodes a transforming activity sufficient for skin tumor formation in transgenic mice

J Invest Dermatol. 2008 Sep;128(9):2142-4. doi: 10.1038/jid.2008.217.

Abstract

Infections with beta-genus human papillomaviruses (HPVs) have been associated with nonmelanoma skin cancers, particularly in immunocompromised patients and individuals with a rare genetic disease, epidermodysplasia verruciformis (EV). Using a transgenic mouse model, Herbert Pfister's group determined that expression of the HPV8 E2 gene results in skin cancer development and that this process is greatly accelerated by UV irradiation (Pfefferle et al., 2008, this issue).

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / radiation effects
  • Disease Models, Animal
  • Gene Expression Regulation, Viral / physiology*
  • Genes, Viral / physiology*
  • Humans
  • Mice
  • Mice, Transgenic
  • Neoplasms, Radiation-Induced / genetics
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / physiology*
  • Papillomavirus Infections / complications
  • Skin Neoplasms / genetics
  • Skin Neoplasms / physiopathology*
  • Skin Neoplasms / virology*
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Ultraviolet Rays / adverse effects

Substances

  • Oncogene Proteins, Viral
  • Trans-Activators
  • oncogene protein E2, Human papillomavirus type 8