Abstract
MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA Replication / genetics*
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Genes, myc*
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Humans
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Methylation
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Models, Biological
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Models, Genetic
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Neoplasms / genetics
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Neoplasms / metabolism
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Protein Biosynthesis*
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism
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RNA Caps / genetics
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RNA Caps / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Proto-Oncogene Proteins c-myc
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RNA Caps
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RNA, Messenger
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Transcription Factors