Abstract
Transcription factors are a large class of biological molecules that are important for health and disease. Despite that there are challenges to targeting them therapeutically and most approaches alter their activity indirectly. Research at the chemical biology interface has led to the development of new ways of targeting transcription factors including blocking transcription factor dimerisation, targeting specific DNA sequences and DNA decoys. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Base Sequence
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DNA / metabolism
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Dimerization
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Humans
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Models, Biological
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / metabolism
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Neuroblastoma / drug therapy
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Neuroblastoma / metabolism
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Protein Transport
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Repressor Proteins / metabolism
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / metabolism*
Substances
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Antineoplastic Agents
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NF-kappa B
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RE1-silencing transcription factor
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Repressor Proteins
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Transcription Factors
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DNA