Invasive rhino-orbital fungal sinusitis following dental manipulation

Mycoses. 2009 Jul;52(4):368-71. doi: 10.1111/j.1439-0507.2008.01600.x. Epub 2008 Aug 13.

Abstract

Rhinocerebral mucormycosis is a fulminant fungal infection of the nose and paranasal sinuses in immunocompromised patients. But mucormycosis following dental manipulation in immunocompetent patients leading to orbital involvement is rare. The objective of this study was to highlight the variable presentations of mucormycosis. We had two immunocompetent patients, who had undergone some dental treatment by quacks, later developed fulminant mucormycosis of the paranasal sinuses and blindness. The endoscopic sinus surgery and Amphotericin B chemotherapy resulted in a good outcome. This disease requires an aggressive approach of combined endoscopic sinus surgery and Amphotericin B to increase the chances of survival in these patients.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Dental Care / adverse effects*
  • Fungi / isolation & purification
  • Fungi / physiology
  • Humans
  • Male
  • Mucormycosis / drug therapy
  • Mucormycosis / etiology*
  • Mucormycosis / microbiology
  • Orbital Diseases / drug therapy
  • Orbital Diseases / etiology*
  • Orbital Diseases / microbiology
  • Sinusitis / drug therapy
  • Sinusitis / microbiology*
  • Sinusitis / mortality
  • Young Adult

Substances

  • Antifungal Agents