Ring expansion of lactones and lactams via propiolate 1-carbon intercalation

Org Lett. 2008 Sep 18;10(18):3985-8. doi: 10.1021/ol8014682. Epub 2008 Aug 16.

Abstract

Readily available five- and six-membered lactones and N-sulfonyllactams undergo efficient addition of t-butyl propiolate, and the resulting adducts undergo cycloisomerization to six- and seven-membered cyclic ethers or amines in the presence of pyridinium acetate. The ring expansion process occurs in generally good yields and is proposed to involve a nucleophilic catalysis mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbon / chemistry*
  • Cyclization
  • Intercalating Agents / chemistry*
  • Isomerism
  • Lactams / chemistry*
  • Lactones / chemistry*
  • Propionates / chemistry*

Substances

  • Alkynes
  • Intercalating Agents
  • Lactams
  • Lactones
  • Propionates
  • Carbon
  • propiolic acid