Post-PCI fatal bleeding in aspirin and clopidogrel hyper responder: shifting from antiplatelet resistance to bleeding risk assessment?

Thomas Cuisset; Corinne Frere; Jacques Quilici; Sabrina Uhry; Marie Christine Alessi; Jean Louis Bonnet

doi:10.1016/j.ijcard.2008.06.044

Post-PCI fatal bleeding in aspirin and clopidogrel hyper responder: shifting from antiplatelet resistance to bleeding risk assessment?

Int J Cardiol. 2010 Jan 21;138(2):212-3. doi: 10.1016/j.ijcard.2008.06.044. Epub 2008 Aug 15.

Authors

Thomas Cuisset, Corinne Frere, Jacques Quilici, Sabrina Uhry, Marie Christine Alessi, Jean Louis Bonnet

PMID: 18707772
DOI: 10.1016/j.ijcard.2008.06.044

Abstract

A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel. At hospital discharge, platelet testing showed hyper response to antiplatelet therapy with very low post treatment platelet reactivity.

Publication types

Case Reports
Letter

MeSH terms

Acute Coronary Syndrome / drug therapy*
Acute Coronary Syndrome / epidemiology
Aspirin / administration & dosage
Aspirin / adverse effects*
Blood Platelets / drug effects
Clopidogrel
Fatal Outcome
Female
Humans
Intracranial Hemorrhages / chemically induced*
Intracranial Hemorrhages / epidemiology
Middle Aged
Platelet Aggregation Inhibitors / administration & dosage
Platelet Aggregation Inhibitors / adverse effects
Risk Assessment
Risk Factors
Ticlopidine / administration & dosage
Ticlopidine / adverse effects
Ticlopidine / analogs & derivatives*

Substances

Platelet Aggregation Inhibitors
Clopidogrel
Ticlopidine
Aspirin