Identification of cis-acting sites for condensin loading onto budding yeast chromosomes

Genes Dev. 2008 Aug 15;22(16):2215-27. doi: 10.1101/gad.1675708.

Abstract

Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and SNR genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / physiology*
  • Binding Sites
  • Cell Cycle
  • Cell Cycle Proteins
  • Chromatin Assembly and Disassembly
  • Chromatin Immunoprecipitation
  • Chromosomal Proteins, Non-Histone
  • Chromosomes, Fungal / genetics*
  • Cohesins
  • DNA-Binding Proteins / physiology*
  • Fungal Proteins / physiology
  • Mitosis*
  • Multiprotein Complexes / physiology*
  • RNA Polymerase III / metabolism
  • RNA, Transfer / genetics
  • Saccharomycetales / cytology
  • Saccharomycetales / genetics
  • Saccharomycetales / metabolism*
  • Transcription Factors, TFIII / physiology*
  • Transcription, Genetic*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Fungal Proteins
  • Multiprotein Complexes
  • Transcription Factors, TFIII
  • condensin complexes
  • transcription factor TFIIIC
  • RNA, Transfer
  • RNA Polymerase III
  • Adenosine Triphosphatases