C-C bond-forming desulfurizations of sulfoximines

Org Lett. 2008 Sep 18;10(18):4081-4. doi: 10.1021/ol8015995. Epub 2008 Aug 20.

Abstract

Highly substituted, enantiomerically pure azaheterocyclic ring systems play an important role in medicinal chemistry as potential peptide mimetics. Metalated 2-alkenyl sulfoximines offer an efficient entry to this class of compounds. In this paper, we describe a new means to remove the sulfonimidoyl auxiliary with concomitant formation of a C-C double bond.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Methionine Sulfoximine / analogs & derivatives*
  • Methionine Sulfoximine / chemistry*
  • Sulfur / chemistry*

Substances

  • Methionine Sulfoximine
  • Sulfur
  • Carbon