Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial

J Clin Periodontol. 2008 Oct;35(10):877-84. doi: 10.1111/j.1600-051X.2008.01303.x. Epub 2008 Aug 17.

Abstract

Objective: The aim of this study was to assess the effect of adjunctive antimicrobial photodynamic therapy (aPDT) in chronic periodontitis.

Material and methods: Twenty patients with untreated chronic periodontitis were included. All teeth received periodontal treatment comprising scaling and root planing. Using a split-mouth design, two quadrants (test group) were additionally treated with aPDT. Sulcus fluid flow rate (SFFR) and bleeding on probing (BOP) were assessed at baseline, 1 week and 3 months after treatment. Relative attachment level (RAL), probing depths (PDs) and gingival recession (GR) were evaluated at baseline and 3 months after treatment.

Results: Baseline median values for PD, GR and RAL were not different in the test group and control group. Values for RAL, PD, SFFR and BOP decreased significantly 3 months after treatment in the control group (median delta RAL: -0.35 mm, inter-quartile range: 0.21 mm), with a higher impact on the sites treated with adjunctive aPDT (median delta RAL: -0.67 mm, inter-quartile range: 0.36 mm, p<0.05). GR increased 3 months after treatment with and without adjunctive aPDT (p<0.05), with no difference between the groups (p>0.05).

Conclusions: In patients with chronic periodontitis, clinical outcomes of conventional subgingival debridement can be improved by adjunctive aPDT.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chronic Periodontitis / complications
  • Chronic Periodontitis / drug therapy*
  • Combined Modality Therapy
  • Dental Deposits / complications
  • Dental Deposits / prevention & control*
  • Dental Scaling*
  • Female
  • Gingiva / radiation effects
  • Humans
  • Low-Level Light Therapy / instrumentation
  • Low-Level Light Therapy / methods*
  • Male
  • Middle Aged
  • Periodontal Attachment Loss / complications
  • Periodontal Attachment Loss / drug therapy
  • Periodontal Index
  • Phenothiazines / therapeutic use
  • Photochemotherapy / methods*
  • Photosensitizing Agents / therapeutic use
  • Single-Blind Method
  • Statistics, Nonparametric
  • Treatment Outcome

Substances

  • Phenothiazines
  • Photosensitizing Agents
  • phenothiazine