Natural infection with Schistosoma mansoni in wild vertebrates and domesticated animals in Brazil is described in this review from an epidemiological viewpoint. Some species of wild rodents are small-sized animals, with a short expectation of life, a limited territory, and present high infection rates under natural conditions. A successful maintenance of the parasite's life cycle under artificial conditions can be achieved with Biomphalaria glabrata. On the other hand, despite showing low natural infection rates, cattle are very susceptible to infection under experimental conditions (using calves of Holstein lineage, cross-bred with the Gir lineage). Due to their large size (just one calf may harbor a number of worms higher than a whole colony of aquatic rodents) and their longevity, cattle are a potential reservoir for the maintenance and dissemination of the disease. There is thus a need of new studies to gain a better understanding about the actual role of these animals in the epidemiology of S. mansoni.