Intra-arterial chemotherapy for head and neck cancer: experiences from three continents

K Thomas Robbins; Akihiro Homma

doi:10.1016/j.soc.2008.04.015

Intra-arterial chemotherapy for head and neck cancer: experiences from three continents

Surg Oncol Clin N Am. 2008 Oct;17(4):919-33, xi. doi: 10.1016/j.soc.2008.04.015.

Authors

K Thomas Robbins¹, Akihiro Homma

Affiliation

¹ SimmonsCooper Cancer Institute at SIU, Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794-9677, USA. [email protected]

PMID: 18722926
DOI: 10.1016/j.soc.2008.04.015

Abstract

Intra-arterial infusion of chemotherapy agents for cancer of the head and neck has been used for several decades. This article provides the rationale, historical background, and current state of investigations for patients treated in this manner. The experience with this route of drug delivery comes from three geographic regions: Europe, Japan, and North America. While the results of the trials have yet to establish the approach as being superior to intravenous infusions, continued research is warranted.

Publication types

Review

MeSH terms

Antineoplastic Agents / administration & dosage*
Chemotherapy, Cancer, Regional Perfusion*
Clinical Trials as Topic*
Head and Neck Neoplasms / drug therapy*
Head and Neck Neoplasms / mortality
Humans

Substances

Antineoplastic Agents