Abstract
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoimmune Diseases
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Autoimmunity*
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DNA, Single-Stranded / immunology*
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Exodeoxyribonucleases / immunology*
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Humans
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Interferon Type I / immunology
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Mice
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Phosphoproteins / immunology*
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Retroelements / immunology*
Substances
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DNA, Single-Stranded
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Interferon Type I
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Phosphoproteins
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Retroelements
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Exodeoxyribonucleases
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three prime repair exonuclease 1