Abstract
Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that exhibits highly specific lytic activity against polymorphonuclear cells, monocytes, and macrophages. A 34-year-old man admitted for right parietal brain abscess and thickened dura mater in close proximity to a lytic bone lesion is presented. The abscess culture yielded methicillin-sensitive S. aureus that produced PVL. The patient did well after surgery and antibiotic treatment. A hematogenous infection, route of bone infection with progression to dura mater and brain parenchyma was hypothesized. To our knowledge this is the first reported case of a brain abscess due to PVL-positive S. aureus.
MeSH terms
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Adult
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Anti-Bacterial Agents / therapeutic use
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Bacterial Toxins / biosynthesis*
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Bacterial Toxins / genetics
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Brain Abscess / drug therapy
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Brain Abscess / microbiology*
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Brain Abscess / surgery
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Drainage
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Exotoxins / biosynthesis*
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Exotoxins / genetics
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Head / diagnostic imaging
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Humans
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Leukocidins / biosynthesis*
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Leukocidins / genetics
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Magnetic Resonance Imaging
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Male
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Radiography
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Staphylococcal Infections / complications*
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / surgery
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification*
Substances
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Anti-Bacterial Agents
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin