Abstract
Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the efficacy of selective cathepsin S inhibitors as antihyperalgesics in a model of neuropathic pain in rats after oral administration.
MeSH terms
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Administration, Oral
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Analgesics / administration & dosage
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Analgesics / pharmacokinetics
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Analgesics / therapeutic use*
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Animals
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Biological Availability
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Cathepsins / antagonists & inhibitors*
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Cysteine Proteinase Inhibitors / administration & dosage
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Cysteine Proteinase Inhibitors / pharmacokinetics
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Cysteine Proteinase Inhibitors / therapeutic use*
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Peripheral Nervous System Diseases / drug therapy*
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Peripheral Nervous System Diseases / enzymology
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Rats
Substances
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Analgesics
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Cysteine Proteinase Inhibitors
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Cathepsins
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cathepsin S