Abstract
Podosomes are specialized adhesion sites found in rapidly migrating and invasive cells, most notably in cells from the myeloid lineage that participate in immune surveillance and phagocyte defence mechanisms. In this review, we describe the nature of leukocyte podosomes and the regulation of their turnover during migration by the key regulatory molecules Wiskott-Aldrich syndrome protein and WASP-interacting protein.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Movement*
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Cytoskeletal Proteins / metabolism*
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Intracellular Signaling Peptides and Proteins / metabolism*
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Leukocytes / diagnostic imaging
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Leukocytes / physiology*
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Models, Biological
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Ultrasonography
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Wiskott-Aldrich Syndrome Protein / metabolism*
Substances
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Cytoskeletal Proteins
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Intracellular Signaling Peptides and Proteins
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WIPF1 protein, human
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Wiskott-Aldrich Syndrome Protein