Abstract
Some patients with initially unresectable hepatic colorectal cancer metastases can be effectively treated with neoadjuvant chemotherapy to allow operative resection in curative intent. Here, we report on a patient with unresectable locoregional recurrence of colon cancer, which was down-staged using combination chemotherapy with infusional 5-fluorouracil, folinic acid, oxaliplatin and cetuximab. After 12 weeks of therapy a partial response was documented and 3 weeks later the tumor was completely resected without increased perioperative morbidity. Therefore, neoadjuvant treatment with molecular targeted agents in combination with chemotherapy can also be an option to enable selected patients with locoregional recurrence to undergo surgical resection in curative intent.
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / pathology
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Adenocarcinoma / secondary*
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Adenocarcinoma / surgery
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal, Humanized
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cetuximab
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Colectomy
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Colonic Neoplasms / surgery
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Combined Modality Therapy
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Fluorouracil / administration & dosage
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Humans
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Leucovorin / administration & dosage
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Male
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Middle Aged
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Neoadjuvant Therapy*
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Neoplasm Invasiveness
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Neoplasm Staging
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Neoplastic Cells, Circulating
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Reoperation
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Retroperitoneal Neoplasms / drug therapy
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Retroperitoneal Neoplasms / pathology
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Retroperitoneal Neoplasms / secondary*
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Retroperitoneal Neoplasms / surgery
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Cetuximab
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Leucovorin
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Fluorouracil