The serious side-effects and complications related to the life-long use of immunosuppressors in transplantation have fuelled research into their possible minimization or even complete elimination. The field of transplantation is therefore tentatively moving from a phase of empiric immunosuppression towards individualized therapy. This process is highly dependent on the development of immune monitoring tests to detect an individual 'level of risk'. Immune monitoring is a way of measuring functional and molecular correlates of immune reactivity to provide clinically useful information for therapeutic decision-making. The technological breakthroughs over the last decade provide firm grounds for the achievement of this goal. Large, multicentric and prospective studies in the near future are now crucial if these tests are to achieve the necessary approval from the regulatory authorities and promptly enter the clinic for routine use.