Abstract
Solid-organ transplant patients can have a number of complications, some of which are particularly severe with regard to morbidity and mortality. These complications may be due to operative and post-operative complications or to the immunosuppressive therapy regimen. Renal impairment is a frequent post-transplant complication that may occur for any number of reasons, including peri-operative ischemic events and nephrotoxicity secondary to anti-rejection medications. Calcineurin inhibitors (CNIs) in particular can lead to acute renal failure (ARF). There are no clear guidelines for the management of ARF after heart transplantation. Different strategies include delaying initiation of CNI therapy post transplant, and the use of anti-CD25 monoclonal antibodies.
MeSH terms
-
Acute Kidney Injury / etiology
-
Adult
-
Antibodies, Monoclonal / therapeutic use*
-
Antigens, CD / blood
-
Basiliximab
-
Calcineurin / adverse effects*
-
Cardiomyopathies / surgery*
-
Drug Administration Schedule
-
Female
-
Graft Rejection / prevention & control
-
Graft Survival / drug effects
-
Graft Survival / immunology
-
Heart Arrest / etiology
-
Heart Transplantation / immunology*
-
Humans
-
Immunosuppressive Agents / therapeutic use*
-
Interleukin-2 Receptor alpha Subunit / blood
-
Kidney / drug effects
-
Kidney / immunology
-
Kidney / physiology*
-
Postoperative Complications / diagnosis
-
Recombinant Fusion Proteins / therapeutic use*
-
Treatment Outcome
-
Ventricular Dysfunction, Right / diagnosis*
-
Waiting Lists
Substances
-
Antibodies, Monoclonal
-
Antigens, CD
-
Immunosuppressive Agents
-
Interleukin-2 Receptor alpha Subunit
-
Recombinant Fusion Proteins
-
Basiliximab
-
Calcineurin