Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13679-84. doi: 10.1073/pnas.0805901105. Epub 2008 Sep 2.

Abstract

Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression. Jumonji C (jmjC) domain-containing proteins have been shown to reverse histone methylation in nonplant model systems. Here, we show that plant Jumonji C proteins have both conserved and specific features compared with mammalian homologues. In particular, the rice JMJD2 family jmjC gene JMJ706 is shown to encode a heterochromatin-enriched protein. The JMJ706 protein specifically reverses di- and trimethylations of lysine 9 of histone H3 (H3K9) in vitro. Loss-of-function mutations of the gene lead to increased di- and trimethylations of H3K9 and affect the spikelet development, including altered floral morphology and organ number. Gene expression and histone modification analysis indicates that JMJ706 regulates a subset of flower development regulatory genes. Taken together, our data suggest that rice JMJ706 encodes a heterochromatin-associated H3K9 demethylase involved in the regulation of flower development in rice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Flowers / enzymology*
  • Flowers / growth & development*
  • Flowers / ultrastructure
  • Gene Expression Regulation, Plant
  • Histones / metabolism
  • Methylation
  • Microscopy, Electron
  • Mutation / genetics
  • Oryza / enzymology*
  • Oryza / genetics
  • Oryza / growth & development*
  • Oryza / ultrastructure
  • Oxidoreductases, N-Demethylating / genetics
  • Oxidoreductases, N-Demethylating / metabolism*
  • Phylogeny

Substances

  • DNA-Binding Proteins
  • Histones
  • Oxidoreductases, N-Demethylating

Associated data

  • RefSeq/NP_001065492