Photoactivity of kynurenine-derived UV filters

J Photochem Photobiol B. 2008 Dec 11;93(3):127-32. doi: 10.1016/j.jphotobiol.2008.07.006. Epub 2008 Aug 6.

Abstract

Quantum yields of photodecomposition and triplet state formation under aerobic and anaerobic conditions are determined for kynurenine (KN), 3-hydroxykynurenine (3OHKN), xanthurenic acid (XAN), and kynurenine adducts of glutathione (GSH-KN), cysteine (Cys-KN), histidine (His-KN), and lysine (Lys-KN) in aqueous solutions. The highest yields of anaerobic photodecomposition were obtained for GSH-KN and His-KN adducts, which correlates with the highest triplet yields for these compounds. In aerobic conditions, the photodecomposition yields for all compounds under study increase; the highest decomposition rates were observed for His-KN and 3OHKN. The fast decomposition of the latter is attributed to the dark autoxidation of the starting compound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaerobiosis
  • Cysteine / chemistry
  • Cysteine / radiation effects
  • Glutathione / chemistry
  • Glutathione / radiation effects
  • Histidine / chemistry
  • Histidine / radiation effects
  • Kynurenine / chemistry
  • Kynurenine / radiation effects*
  • Photolysis*
  • Quantum Theory
  • Scattering, Radiation
  • Time Factors
  • Ultraviolet Rays*

Substances

  • Kynurenine
  • Histidine
  • Glutathione
  • Cysteine