Abstract
Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Genistein / pharmacology
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Humans
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Molecular Structure
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Neutrophils / drug effects
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Neutrophils / enzymology
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Nuclear Magnetic Resonance, Biomolecular
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Pancreatic Elastase / biosynthesis
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Pancreatic Elastase / drug effects
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Taiwan
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Diterpenes
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Genistein
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Pancreatic Elastase