Abstract
Fluorescent nucleoside analogues were synthesized and derived to protected nucleoside phosphoramidite. The nucleoside analogue bearing 3-aminobenzonitrile was sensitive to the surrounding environment. 3-Aminobenzonitrile is a similar size with pyrimidine base. Therefore, it is expected that the nucleoside little perturbs the formation of duplex. This nucleoside could be incorporated into DNA.
MeSH terms
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Aniline Compounds / chemical synthesis
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Aniline Compounds / chemistry*
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DNA / chemistry
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Fluorescent Dyes / chemistry*
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Oligodeoxyribonucleotides / chemical synthesis
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Oligodeoxyribonucleotides / chemistry*
Substances
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6-(2-deoxyribofuranosyl)-3-aminobenzonitrile
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Aniline Compounds
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Fluorescent Dyes
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Nucleosides
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Oligodeoxyribonucleotides
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DNA