Abstract
Brain-derived neurotrophic factor (BDNF) has been shown to influence monoamine transmitter synthesis, metabolism and release. We investigated possible relationships between four BDNF gene polymorphisms and cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 132). All BDNF polymorphisms (270 C/T, -633 T/A, Val66Met, and 11757 G/C) were associated with MHPG (P < 0.02), but not with 5-HIAA and HVA concentrations. At a second clinical investigation 8-20 years after CSF sampling 30% of the subjects had experienced various psychiatric disorders. Development of a psychiatric disorder was predicted by low 5-HIAA concentrations (P = 0.01). The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Brain / metabolism*
-
Brain Chemistry / genetics
-
Brain-Derived Neurotrophic Factor / genetics*
-
DNA Mutational Analysis
-
Female
-
Gene Frequency / genetics
-
Genetic Predisposition to Disease / genetics
-
Genetic Testing
-
Genotype
-
Homovanillic Acid / analysis
-
Homovanillic Acid / cerebrospinal fluid
-
Humans
-
Hydroxyindoleacetic Acid / analysis
-
Hydroxyindoleacetic Acid / cerebrospinal fluid
-
Male
-
Methoxyhydroxyphenylglycol / analysis
-
Methoxyhydroxyphenylglycol / cerebrospinal fluid*
-
Neurocognitive Disorders / genetics
-
Neurocognitive Disorders / metabolism
-
Neurocognitive Disorders / physiopathology
-
Norepinephrine / metabolism*
-
Polymorphism, Genetic / genetics*
-
Predictive Value of Tests
-
Serotonin / metabolism
-
Young Adult
Substances
-
Brain-Derived Neurotrophic Factor
-
Serotonin
-
Methoxyhydroxyphenylglycol
-
Hydroxyindoleacetic Acid
-
Norepinephrine
-
Homovanillic Acid