Dexamphetamine normalises electrophysiological activity in attention deficit-hyperactivity disorder during the Stroop task

Neurocase. 2007 Oct;13(5):301-10. doi: 10.1080/13554790701770850.

Abstract

A case study was conducted to investigate whether dexamphetamine enhances interference control in an adult with attention deficit/hyperactivity disorder. Continuous electroencephalography was recorded both on and off dexamphetamine during performance on a Stroop task. An age-, gender- and IQ-matched control also completed the same task. Event related potentials for the control participant revealed a positive potential to incongruent stimuli between 270 and 440 ms, whereas for the participant with attention deficit/hyperactivity disorder off medication, the reverse polarity was observed in a later time window. Following administration of dexamphetamine, however, the event-related potentials for the incongruent condition closely resembled those in the control, suggesting that dexamphetamine successfully normalises electroencephalographic activity.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention / drug effects*
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Attention Deficit Disorder with Hyperactivity / physiopathology
  • Case-Control Studies
  • Central Nervous System Stimulants / pharmacology*
  • Conflict, Psychological
  • Contingent Negative Variation / drug effects*
  • Dextroamphetamine / pharmacology*
  • Discrimination, Psychological / drug effects
  • Electroencephalography / drug effects
  • Humans
  • Inhibition, Psychological*
  • Male
  • Matched-Pair Analysis
  • Pattern Recognition, Visual / drug effects
  • Reaction Time / drug effects
  • Reference Values

Substances

  • Central Nervous System Stimulants
  • Dextroamphetamine