Recently, we reported the effectiveness of a health education activity for multi-risk workers. In this study, we investigated whether or not the efficacy of the 1-year health education program persists in the medium run. BMI, systolic blood pressure and triglyceride out of 5 items which improved significantly after a 1-year health education program, persisted after 3-5 years. Total cholesterol improved additionally while systolic blood pressure deteriorated. A gamma-GTP, which did not show betterment significantly, was enhanced after 3-5 years. The percentage of those who are following a good lifestyle regarding excise, alcohol and nutrition, increased after 3-5 years than before the education program. The efficacy of the health education activity for multi-risk workers continues in the medium run.