Abstract
The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Cell Line, Tumor
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Cell Membrane / metabolism
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Disease Progression
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Female
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Genes, ras
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Humans
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Male
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Middle Aged
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Mutation*
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Pancreatic Neoplasms / genetics*
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Pancreatic Neoplasms / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-akt / genetics*
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Proto-Oncogene Proteins c-akt / metabolism
Substances
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Phosphatidylinositol 3-Kinases
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AKT1 protein, human
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Proto-Oncogene Proteins c-akt