Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism

J Invest Dermatol. 2008 Oct;128(10):2357-61. doi: 10.1038/jid.2008.249.

Abstract

More than 1 million skin cancers occur annually in the United States--of which 80% are basal-cell carcinoma (BCC), 16% are squamous-cell carcinoma (SCC), and 4% are melanomas--making skin cancer by far the most common cancer (Greenlee et al., 2001). UVR is the major etiologic agent. UV wavelengths shorter than 280 nm (UVC) are absorbed by the ozone layer and do not reach the earth. UV wavelengths longer than 320 nm (UVA) have limited ability to induce the characteristic mutations in DNA seen in epidermal cancers. Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?

Publication types

  • Comment
  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Humans
  • Neoplasms, Radiation-Induced / prevention & control*
  • Receptors, Calcitriol / metabolism*
  • Skin / metabolism
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / prevention & control*
  • Tumor Suppressor Proteins / metabolism
  • Ultraviolet Rays / adverse effects*
  • Vitamin D / metabolism

Substances

  • Receptors, Calcitriol
  • Tumor Suppressor Proteins
  • Vitamin D