Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action

Brain Res Bull. 2009 Feb 16;78(2-3):75-9. doi: 10.1016/j.brainresbull.2008.08.013. Epub 2008 Sep 13.

Abstract

The centromedian (CM)-parafascicular (PF) nuclear complex in the primate thalamus has reciprocal and specific connections with the basal ganglia. It has been argued that the thalamic CM-PF complex has a role in pain processing and attention. However, the functional relationship of this complex with the basal ganglia, which is considered to have a role in goal-directed movement, has not been well characterized. Here we present a hypothetical view that the thalamic CM-PF complex-basal ganglia circuit plays complementary roles in response bias. The basal ganglia are involved in creating 'reward-based pre-action bias', which facilitates the selection and execution of an action associated with a higher value. In contrast, when an action with a lower value is unexpectedly requested, the CM-PF induces an 'externally driven rebiasing' process in the striatum that aborts the pre-action bias and assists selecting and executing actions appropriate for unexpected situations. This model provides a framework for how the thalamic CM-PF complex and the basal ganglia function together in general for unexpected situations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basal Ganglia / anatomy & histology
  • Basal Ganglia / physiology*
  • Humans
  • Intralaminar Thalamic Nuclei / anatomy & histology
  • Intralaminar Thalamic Nuclei / cytology
  • Intralaminar Thalamic Nuclei / physiology*
  • Models, Biological
  • Movement / physiology
  • Nerve Net / anatomy & histology
  • Nerve Net / physiology
  • Neural Pathways / anatomy & histology
  • Neural Pathways / physiology*
  • Thalamus / anatomy & histology
  • Thalamus / physiology*