Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual

Eur J Clin Pharmacol. 2009 Jan;65(1):97-100. doi: 10.1007/s00228-008-0559-6. Epub 2008 Sep 17.

Authors

Andrea Gaedigk¹, Dorothee Frank, Uwe Fuhr

Affiliation

¹ Section of Developmental Pharmacology and Experimental Therapeutics, Children's Mercy Hospital & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA. [email protected]

PMID: 18797858
DOI: 10.1007/s00228-008-0559-6

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Biotransformation
Cytochrome P-450 CYP2D6 / genetics*
Cytochrome P-450 CYP2D6 / metabolism
DNA Mutational Analysis
Dextromethorphan / pharmacokinetics
Dextromethorphan / urine
Haplotypes
Humans
Male
Phenotype
Polymorphism, Single Nucleotide
White People / genetics*

Substances

Dextromethorphan
Cytochrome P-450 CYP2D6