A simple electrical-mechanical model of the heart applied to the study of electrical-mechanical alternans

IEEE Trans Biomed Eng. 1991 Jun;38(6):551-60. doi: 10.1109/10.81580.

Abstract

Recent evidence has shown that a subtle alternation in the surface ECG (electrical alternans) may be correlated with the susceptibility to ventricular fibrillation. This paper presents evidence that a mechanical alternation in the heart beat (mechanical alternans) generally accompanies electrical alternans. A simple finite-element computer model, which emulates both the electrical and mechanical activity of the heart, is presented. A pilot animal study is also reported. The computer model and the animal study both found that 1) there exists a regime of combined electrical-mechanical alternans during the transition from a normal rhythm towards a fibrillatory rhythm, 2) the detected degree of alternation is correlated with the relative instability of the rhythm, and 3) the electrical and mechanical alternans may result from a dispersion in local electrical properties leading to a spatial-temporal alternation in the electrical conduction process.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Computer Simulation*
  • Dogs
  • Electric Conductivity
  • Electrocardiography*
  • Humans
  • Models, Cardiovascular*
  • Ventricular Fibrillation / physiopathology