Objective: To study the correlation of OX40 Gene rs17568A/G polymorphism with acute coronary syndrome in Chinese Han population.
Methods: 228 ACS patients and 165 matched controls of Chinese Han population were selected to study the OX40 gene rs17568A/G polymorphism with PCR-RFLP method. DNA sequences of enzyme digested products were also analyzed.
Results: All three genotypes, AA, AG and GG, were existed both in ACS patients and control group. OX40 gene rs17568A/G polymorphism frequencies were 29.4% for patients and 26.7% for control group respectively, in which the statistic significance was not observed (P > 0.05). Besides, no significant differences were found for G allele and genotype frequencies in different severity of coronary lesion. But the results demonstrated that the presence of G allele was associated with high density lipoprotein (HDL) cholesterol concentration in either patients or controls.
Conclusions: OX40 gene rs17568A/G polymorphism was not associated with acute coronary syndrome in Chinese population, however, this polymorphism has some influence on serum HDL-C level in Chinese population.