Coordinating development of medullary thymic epithelial cells

Immunity. 2008 Sep 19;29(3):386-8. doi: 10.1016/j.immuni.2008.09.001.

Abstract

Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.

Publication types

  • Comment

MeSH terms

  • AIRE Protein
  • Animals
  • Autoimmunity
  • CD40 Antigens / metabolism
  • CD40 Ligand / metabolism
  • Epithelial Cells / cytology
  • Epithelial Cells / immunology*
  • Humans
  • Mice
  • Mice, Knockout
  • RANK Ligand / metabolism
  • Receptor Activator of Nuclear Factor-kappa B / metabolism
  • Receptors, Antigen, T-Cell / metabolism
  • Self Tolerance
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • Thymus Gland / cytology
  • Thymus Gland / immunology*
  • Thymus Gland / physiology
  • Transcription Factors / metabolism

Substances

  • CD40 Antigens
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Receptors, Antigen, T-Cell
  • Transcription Factors
  • CD40 Ligand